Drug interactions
Azilsartan-chlorthalidone + Methoxsalen
Severity: Moderate
Azilsartan-chlorthalidone and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone is a recognized photosensitizing drug and methoxsalen is a potent photosensitizer used with UVA therapy. Concurrent use may increase the risk of phototoxic reactions such as severe sunburn.
What this interaction means in plain words
Azilsartan-chlorthalidone and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitizing effects of both agents.
What to do
Carefully titrate UVA exposure and counsel the patient on strict sun protection. Monitor skin for phototoxic reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Methoxsalen?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone is a recognized photosensitizing drug and methoxsalen is a potent photosensitizer used with UVA therapy. Concurrent use may increase the risk of phototoxic reactions such as severe sunburn.
How serious is the interaction between Azilsartan-chlorthalidone and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Carefully titrate UVA exposure and counsel the patient on strict sun protection. Monitor skin for phototoxic reactions.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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