Drug interactions
Azilsartan-chlorthalidone + Nadolol
Severity: Minor
Azilsartan-chlorthalidone and Nadolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding nadolol to an ARB plus thiazide-like diuretic gives additive blood pressure reduction, which can cause excessive hypotension or bradycardia in some patients. Potassium effects are opposing and small, so the net change is hard to predict.
What this interaction means in plain words
Azilsartan-chlorthalidone and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects, with opposing minor effects on serum potassium.
What to do
Monitor blood pressure, heart rate and serum potassium when starting or adjusting therapy. Reduce doses if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Nadolol
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Nadolol?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Nadolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Adding nadolol to an ARB plus thiazide-like diuretic gives additive blood pressure reduction, which can cause excessive hypotension or bradycardia in some patients. Potassium effects are opposing and small, so the net change is hard to predict.
How serious is the interaction between Azilsartan-chlorthalidone and Nadolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when starting or adjusting therapy. Reduce doses if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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