Drug interactions
Azilsartan-chlorthalidone + Oxaprozin
Severity: Major
Azilsartan-chlorthalidone and Oxaprozin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin, like other NSAIDs, can reduce the blood pressure lowering effect of ARBs and diuretics through sodium and fluid retention. Together with an ARB and diuretic it increases the risk of acute kidney injury, particularly in older or volume-depleted patients, and may raise potassium.
What this interaction means in plain words
Azilsartan-chlorthalidone and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and antagonizes antihypertensive effects while ARB and diuretic further compromise glomerular filtration.
What to do
Avoid or limit NSAID use to the lowest dose and shortest duration, or use paracetamol. Monitor blood pressure, creatinine and potassium, and keep the patient well hydrated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Oxaprozin?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Oxaprozin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxaprozin, like other NSAIDs, can reduce the blood pressure lowering effect of ARBs and diuretics through sodium and fluid retention. Together with an ARB and diuretic it increases the risk of acute kidney injury, particularly in older or volume-depleted patients, and may raise potassium.
How serious is the interaction between Azilsartan-chlorthalidone and Oxaprozin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit NSAID use to the lowest dose and shortest duration, or use paracetamol. Monitor blood pressure, creatinine and potassium, and keep the patient well hydrated.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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