Drug interactions
Azilsartan-chlorthalidone + Pivmecillinam
Severity: Minor
Azilsartan-chlorthalidone and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pivmecillinam is converted to mecillinam, which is eliminated by the kidney, and thiazide-type diuretics could reduce renal clearance of some penicillins. The clinical effect is likely small and the interaction is not well documented.
What this interaction means in plain words
Azilsartan-chlorthalidone and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azilsartan-chlorthalidone belongs to Cardiovascular; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion or reduced renal clearance; the mechanism is not firmly established.
What to do
No dose adjustment is usually needed. Monitor renal function and for signs of antibiotic adverse effects in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Pivmecillinam?
MediHelp rates the interaction as minor. Azilsartan-chlorthalidone and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pivmecillinam is converted to mecillinam, which is eliminated by the kidney, and thiazide-type diuretics could reduce renal clearance of some penicillins. The clinical effect is likely small and the interaction is not well documented.
How serious is the interaction between Azilsartan-chlorthalidone and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor renal function and for signs of antibiotic adverse effects in patients with renal impairment.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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