Drug interactions
Azilsartan-chlorthalidone + Probenecid
Severity: Moderate
Azilsartan-chlorthalidone and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone can raise serum uric acid and may reduce the uricosuric effect of probenecid. Both are organic acids secreted by renal tubular transporters, so competition may alter their handling. The result may be reduced urate-lowering efficacy in gout patients.
What this interaction means in plain words
Azilsartan-chlorthalidone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Competition for renal tubular organic anion secretion, plus diuretic-induced urate retention opposing probenecid's uricosuric action.
What to do
Monitor serum uric acid and gout control and adjust the probenecid dose if needed. Consider an alternative antihypertensive if gout control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Probenecid?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone can raise serum uric acid and may reduce the uricosuric effect of probenecid. Both are organic acids secreted by renal tubular transporters, so competition may alter their handling. The result may be reduced urate-lowering efficacy in gout patients.
How serious is the interaction between Azilsartan-chlorthalidone and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control and adjust the probenecid dose if needed. Consider an alternative antihypertensive if gout control is lost.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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