Drug interactions
Azilsartan-chlorthalidone + Voclosporin
Severity: Major
Azilsartan-chlorthalidone and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause hyperkalemia and nephrotoxicity, and azilsartan adds to hyperkalemia risk and reduces glomerular filtration pressure. The combination can worsen renal function and raise serum potassium, particularly in patients with kidney disease.
What this interaction means in plain words
Azilsartan-chlorthalidone and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azilsartan-chlorthalidone belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Calcineurin inhibitor afferent arteriolar vasoconstriction and reduced potassium excretion add to ARB-induced efferent dilation and reduced aldosterone effect.
What to do
Monitor eGFR and serum potassium closely, particularly after starting or adjusting either drug. Reduce the voclosporin dose or adjust the antihypertensive regimen if renal function declines or hyperkalemia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Voclosporin?
MediHelp rates the interaction as major. Azilsartan-chlorthalidone and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin, a calcineurin inhibitor, can cause hyperkalemia and nephrotoxicity, and azilsartan adds to hyperkalemia risk and reduces glomerular filtration pressure. The combination can worsen renal function and raise serum potassium, particularly in patients with kidney disease.
How serious is the interaction between Azilsartan-chlorthalidone and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor eGFR and serum potassium closely, particularly after starting or adjusting either drug. Reduce the voclosporin dose or adjust the antihypertensive regimen if renal function declines or hyperkalemia develops.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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