Drug interactions
Azithromycin + Deutetrabenazine
Severity: Moderate
Azithromycin and Deutetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine can modestly prolong the QT interval, particularly at higher exposure, and azithromycin also prolongs QT. Combined use may increase the risk of torsades de pointes in patients with predisposing factors.
What this interaction means in plain words
Azithromycin and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Deutetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Check ECG and correct hypokalemia or hypomagnesemia before combining. Avoid in patients with congenital long QT syndrome or bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Azithromycin with Deutetrabenazine?
MediHelp rates the interaction as moderate. Azithromycin and Deutetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine can modestly prolong the QT interval, particularly at higher exposure, and azithromycin also prolongs QT. Combined use may increase the risk of torsades de pointes in patients with predisposing factors.
How serious is the interaction between Azithromycin and Deutetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct hypokalemia or hypomagnesemia before combining. Avoid in patients with congenital long QT syndrome or bradycardia.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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