Drug interactions
Azithromycin + Doxepin
Severity: Moderate
Azithromycin and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin, particularly at antidepressant doses, may prolong the QT interval, and azithromycin can add to this effect. The risk of arrhythmia is higher with electrolyte disturbances or heart disease.
What this interaction means in plain words
Azithromycin and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Doxepin belongs to Dermatology.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG in at-risk patients and correct potassium and magnesium. Consider a non-macrolide antibiotic if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Azithromycin with Doxepin?
MediHelp rates the interaction as moderate. Azithromycin and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin, particularly at antidepressant doses, may prolong the QT interval, and azithromycin can add to this effect. The risk of arrhythmia is higher with electrolyte disturbances or heart disease.
How serious is the interaction between Azithromycin and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in at-risk patients and correct potassium and magnesium. Consider a non-macrolide antibiotic if other QT risk factors are present.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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