Drug interactions
Azithromycin + Fluticasone-vilanterol
Severity: Moderate
Azithromycin and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin has a recognised, though modest, QT-prolonging effect, and vilanterol may add tachycardia and hypokalemia. The combined risk is generally small but relevant in patients with cardiac risk factors.
What this interaction means in plain words
Azithromycin and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation with beta-2 agonist-related hypokalemia and sympathetic stimulation.
What to do
Consider baseline ECG and electrolytes in patients with QT risk factors. Correct hypokalemia and monitor for palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Azithromycin and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin has a recognised, though modest, QT-prolonging effect, and vilanterol may add tachycardia and hypokalemia. The combined risk is generally small but relevant in patients with cardiac risk factors.
How serious is the interaction between Azithromycin and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider baseline ECG and electrolytes in patients with QT risk factors. Correct hypokalemia and monitor for palpitations.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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