Drug interactions
Azithromycin + Ipratropium-salbutamol
Severity: Moderate
Azithromycin and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both salbutamol and azithromycin can prolong the QT interval, and salbutamol can lower potassium. Combined use may raise the risk of torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Azithromycin and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia adding to risk.
What to do
Check potassium and magnesium in patients with risk factors and consider an ECG if there is cardiac disease or other QT-prolonging drugs. Avoid excessive salbutamol dosing during azithromycin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Azithromycin and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both salbutamol and azithromycin can prolong the QT interval, and salbutamol can lower potassium. Combined use may raise the risk of torsades de pointes, especially with other risk factors.
How serious is the interaction between Azithromycin and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium in patients with risk factors and consider an ECG if there is cardiac disease or other QT-prolonging drugs. Avoid excessive salbutamol dosing during azithromycin therapy.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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