Drug interactions
Azithromycin + Maprotiline
Severity: Moderate
Azithromycin and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline can prolong the QT interval and lower the seizure threshold, and azithromycin adds to the QT risk. The combination may increase the chance of ventricular arrhythmias, especially with electrolyte disturbances or heart disease.
What this interaction means in plain words
Azithromycin and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Maprotiline belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Obtain a baseline ECG, correct electrolytes, and monitor the QTc in at-risk patients. Prefer a non-QT-prolonging antibiotic if the patient has known QT prolongation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Azithromycin with Maprotiline?
MediHelp rates the interaction as moderate. Azithromycin and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline can prolong the QT interval and lower the seizure threshold, and azithromycin adds to the QT risk. The combination may increase the chance of ventricular arrhythmias, especially with electrolyte disturbances or heart disease.
How serious is the interaction between Azithromycin and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct electrolytes, and monitor the QTc in at-risk patients. Prefer a non-QT-prolonging antibiotic if the patient has known QT prolongation.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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