Drug interactions
Azithromycin + Memantine-donepezil
Severity: Moderate
Azithromycin and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both donepezil and azithromycin can prolong the QT interval, which may lead to torsades de pointes, particularly in older patients or those with cardiac disease. The absolute risk with a short azithromycin course is low but real.
What this interaction means in plain words
Azithromycin and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Consider a non-QT-prolonging antibiotic in at-risk patients. If used, check ECG and electrolytes beforehand.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Memantine-donepezil?
MediHelp rates the interaction as moderate. Azithromycin and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both donepezil and azithromycin can prolong the QT interval, which may lead to torsades de pointes, particularly in older patients or those with cardiac disease. The absolute risk with a short azithromycin course is low but real.
How serious is the interaction between Azithromycin and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-QT-prolonging antibiotic in at-risk patients. If used, check ECG and electrolytes beforehand.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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