Drug interactions
Azithromycin + Naldemedine
Severity: Minor
Azithromycin and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a P-glycoprotein substrate, and azithromycin may weakly inhibit this transporter. Exposure to naldemedine could rise slightly, increasing gastrointestinal adverse effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Azithromycin and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azithromycin belongs to Anti Bacterial; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Possible P-glycoprotein inhibition by azithromycin increasing naldemedine absorption.
What to do
No dose adjustment is generally needed. Monitor for gastrointestinal adverse effects or opioid withdrawal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Azithromycin with Naldemedine?
MediHelp rates the interaction as minor. Azithromycin and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is a P-glycoprotein substrate, and azithromycin may weakly inhibit this transporter. Exposure to naldemedine could rise slightly, increasing gastrointestinal adverse effects such as abdominal pain and diarrhea.
How serious is the interaction between Azithromycin and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally needed. Monitor for gastrointestinal adverse effects or opioid withdrawal symptoms.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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