Drug interactions
Azithromycin + Quetiapine
Severity: Moderate
Azithromycin and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. The risk is higher with overdose, electrolyte disturbances, bradycardia or other QT-prolonging drugs.
What this interaction means in plain words
Azithromycin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Quetiapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade.
What to do
Correct potassium and magnesium and obtain a baseline ECG in patients with risk factors. Monitor the QTc, and consider a non-QT-prolonging antibiotic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Azithromycin with Quetiapine?
MediHelp rates the interaction as moderate. Azithromycin and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. The risk is higher with overdose, electrolyte disturbances, bradycardia or other QT-prolonging drugs.
How serious is the interaction between Azithromycin and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium and obtain a baseline ECG in patients with risk factors. Monitor the QTc, and consider a non-QT-prolonging antibiotic in high-risk patients.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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