Drug interactions
Azithromycin + Quizartinib
Severity: Major
Azithromycin and Quizartinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib causes dose-related QT prolongation, and azithromycin adds to the risk of torsades de pointes. Labeling advises caution with other QT-prolonging drugs.
What this interaction means in plain words
Azithromycin and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azithromycin belongs to Anti Bacterial; Quizartinib belongs to Oncology.
Why it happens
Additive QT prolongation through delayed cardiac repolarisation.
What to do
Monitor ECG more frequently, correct electrolytes and consider a non-QT-prolonging antibiotic. Reduce or interrupt quizartinib if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Azithromycin with Quizartinib?
MediHelp rates the interaction as major. Azithromycin and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib causes dose-related QT prolongation, and azithromycin adds to the risk of torsades de pointes. Labeling advises caution with other QT-prolonging drugs.
How serious is the interaction between Azithromycin and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG more frequently, correct electrolytes and consider a non-QT-prolonging antibiotic. Reduce or interrupt quizartinib if QTc becomes markedly prolonged.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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