Drug interactions
Azithromycin + Riociguat
Severity: Minor
Azithromycin and Riociguat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat is cleared by several CYP enzymes, and azithromycin is not a clinically meaningful CYP inhibitor. Any increase in riociguat exposure is expected to be small.
What this interaction means in plain words
Azithromycin and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azithromycin belongs to Anti Bacterial; Riociguat belongs to Cardiovascular.
Why it happens
Azithromycin may weakly affect riociguat clearance, but the mechanism is not well established.
What to do
No dose adjustment is usually needed; monitor blood pressure for symptomatic hypotension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Azithromycin with Riociguat?
MediHelp rates the interaction as minor. Azithromycin and Riociguat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Riociguat is cleared by several CYP enzymes, and azithromycin is not a clinically meaningful CYP inhibitor. Any increase in riociguat exposure is expected to be small.
How serious is the interaction between Azithromycin and Riociguat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor blood pressure for symptomatic hypotension.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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