Drug interactions
Azithromycin + Sertraline
Severity: Minor
Azithromycin and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin can prolong the QT interval and sertraline has a small potential for QT effects, so the added risk is generally low. It becomes more relevant in patients with other risk factors for torsades de pointes.
What this interaction means in plain words
Azithromycin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Azithromycin belongs to Anti Bacterial; Sertraline belongs to Central Nervous System.
Why it happens
Possible additive QTc prolongation, with a small contribution from sertraline.
What to do
No routine action is needed in low-risk patients. Check ECG and electrolytes in those with cardiac disease or multiple QT-prolonging drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Azithromycin and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Azithromycin with Sertraline?
MediHelp rates the interaction as minor. Azithromycin and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Azithromycin can prolong the QT interval and sertraline has a small potential for QT effects, so the added risk is generally low. It becomes more relevant in patients with other risk factors for torsades de pointes.
How serious is the interaction between Azithromycin and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed in low-risk patients. Check ECG and electrolytes in those with cardiac disease or multiple QT-prolonging drugs.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
