Drug interactions
Azithromycin + Vardenafil
Severity: Moderate
Azithromycin and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil can modestly prolong the QT interval, and azithromycin is also associated with QT prolongation and rare torsades de pointes. Combined use may add to arrhythmia risk, especially in patients with other risk factors.
What this interaction means in plain words
Azithromycin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Vardenafil belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarisation (QTc interval) by both drugs.
What to do
Avoid the combination in patients with congenital long QT, electrolyte disturbances or other QT-prolonging drugs; consider an ECG and correct potassium and magnesium if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Frequently asked questions
Can I take Azithromycin with Vardenafil?
MediHelp rates the interaction as moderate. Azithromycin and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vardenafil can modestly prolong the QT interval, and azithromycin is also associated with QT prolongation and rare torsades de pointes. Combined use may add to arrhythmia risk, especially in patients with other risk factors.
How serious is the interaction between Azithromycin and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with congenital long QT, electrolyte disturbances or other QT-prolonging drugs; consider an ECG and correct potassium and magnesium if used together.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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