Drug interactions
Azithromycin + Venetoclax
Severity: Moderate
Azithromycin and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Azithromycin may inhibit P-glycoprotein and raise venetoclax exposure, increasing the chance of neutropenia and tumor lysis syndrome. The effect is probably modest compared with strong inhibitors.
What this interaction means in plain words
Azithromycin and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Venetoclax belongs to Miscellaneous.
Why it happens
Inhibition of intestinal P-glycoprotein efflux of venetoclax, increasing its absorption.
What to do
Where possible choose an alternative antibiotic. If used together, monitor blood counts and for signs of tumor lysis or toxicity, and consider reducing the venetoclax dose per labeling for P-gp inhibitors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Azithromycin with Venetoclax?
MediHelp rates the interaction as moderate. Azithromycin and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Azithromycin may inhibit P-glycoprotein and raise venetoclax exposure, increasing the chance of neutropenia and tumor lysis syndrome. The effect is probably modest compared with strong inhibitors.
How serious is the interaction between Azithromycin and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an alternative antibiotic. If used together, monitor blood counts and for signs of tumor lysis or toxicity, and consider reducing the venetoclax dose per labeling for P-gp inhibitors.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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