Drug interactions
Azithromycin + Voclosporin
Severity: Moderate
Azithromycin and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QT interval at supratherapeutic exposures, and azithromycin also prolongs QT. Using both may increase the risk of arrhythmia, particularly with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Azithromycin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azithromycin belongs to Anti Bacterial; Voclosporin belongs to Miscellaneous.
Why it happens
Additive QT prolongation; azithromycin is a weak CYP3A4 and P-gp inhibitor, so voclosporin exposure might also rise slightly.
What to do
Monitor ECG and keep potassium and magnesium within normal range during co-use. Prefer a different antibiotic if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azithromycin
- Azithromycin + Cisapride Contraindicated
- Azithromycin + Domperidone Contraindicated
- Azithromycin + Dronedarone Contraindicated
- Azithromycin + Pimozide Contraindicated
- Azithromycin + Piperaquine Contraindicated
- Azithromycin + Thioridazine Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Azithromycin with Voclosporin?
MediHelp rates the interaction as moderate. Azithromycin and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QT interval at supratherapeutic exposures, and azithromycin also prolongs QT. Using both may increase the risk of arrhythmia, particularly with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Azithromycin and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and keep potassium and magnesium within normal range during co-use. Prefer a different antibiotic if the patient has other QT risk factors.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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