Drug interactions
Aztreonam + Streptomycin
Severity: Minor
Aztreonam and Streptomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aztreonam combined with streptomycin can give additive or synergistic activity against some gram-negative organisms. The pairing is typically therapeutic, but the aminoglycoside retains its toxicity risks.
What this interaction means in plain words
Aztreonam and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aztreonam belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Cell wall disruption by the beta-lactam increases aminoglycoside penetration, giving synergistic killing.
What to do
Monitor renal function and auditory/vestibular function during streptomycin therapy. Limit the duration of aminoglycoside use to what is clinically necessary.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aztreonam
- Aztreonam + Cefoxitin Moderate
- Aztreonam + Cholera vaccine Moderate
- Aztreonam + Microbiota Moderate
- Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Aztreonam + Typhoid vaccine live Moderate
- Amikacin + Aztreonam Minor
Other interactions of Streptomycin
Frequently asked questions
Can I take Aztreonam with Streptomycin?
MediHelp rates the interaction as minor. Aztreonam and Streptomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aztreonam combined with streptomycin can give additive or synergistic activity against some gram-negative organisms. The pairing is typically therapeutic, but the aminoglycoside retains its toxicity risks.
How serious is the interaction between Aztreonam and Streptomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and auditory/vestibular function during streptomycin therapy. Limit the duration of aminoglycoside use to what is clinically necessary.
What other medicines interact with Aztreonam?
MediHelp also lists interactions of Aztreonam with, for example, Cefoxitin, Cholera vaccine, Microbiota. The full list is on the Aztreonam page.
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