Drug interactions
Aztreonam + Tobramycin
Severity: Minor
Aztreonam and Tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aztreonam and tobramycin are frequently used together for serious Pseudomonas and other gram-negative infections, with additive or synergistic antibacterial activity. The benefit is intended, though aminoglycoside nephrotoxicity and ototoxicity remain a concern.
What this interaction means in plain words
Aztreonam and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Aztreonam belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
Why it happens
Beta-lactam-induced cell wall damage enhances intracellular aminoglycoside uptake, producing synergy.
What to do
Monitor tobramycin serum levels and renal function, adjusting the dose accordingly. Use the shortest effective aminoglycoside course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Aztreonam
- Aztreonam + Cefoxitin Moderate
- Aztreonam + Cholera vaccine Moderate
- Aztreonam + Microbiota Moderate
- Aztreonam + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Aztreonam + Typhoid vaccine live Moderate
- Amikacin + Aztreonam Minor
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Aztreonam with Tobramycin?
MediHelp rates the interaction as minor. Aztreonam and Tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Aztreonam and tobramycin are frequently used together for serious Pseudomonas and other gram-negative infections, with additive or synergistic antibacterial activity. The benefit is intended, though aminoglycoside nephrotoxicity and ototoxicity remain a concern.
How serious is the interaction between Aztreonam and Tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tobramycin serum levels and renal function, adjusting the dose accordingly. Use the shortest effective aminoglycoside course.
What other medicines interact with Aztreonam?
MediHelp also lists interactions of Aztreonam with, for example, Cefoxitin, Cholera vaccine, Microbiota. The full list is on the Aztreonam page.
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