Drug interactions
Baclofen + Brompheniramine
Severity: Moderate
Baclofen and Brompheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brompheniramine is a sedating first-generation antihistamine. With baclofen it can add to drowsiness, dizziness and reduced psychomotor performance.
What this interaction means in plain words
Baclofen and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Brompheniramine belongs to Respiratory.
Why it happens
Additive CNS depression from H1-antihistamine effects and baclofen's GABA-B agonism.
What to do
Advise patients to avoid driving and hazardous tasks until the response is known, and consider a non-sedating antihistamine instead. Reduce doses if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Brompheniramine
Frequently asked questions
Can I take Baclofen with Brompheniramine?
MediHelp rates the interaction as moderate. Baclofen and Brompheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brompheniramine is a sedating first-generation antihistamine. With baclofen it can add to drowsiness, dizziness and reduced psychomotor performance.
How serious is the interaction between Baclofen and Brompheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid driving and hazardous tasks until the response is known, and consider a non-sedating antihistamine instead. Reduce doses if sedation is troublesome.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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