Drug interactions
Baclofen + Carbinoxamine
Severity: Moderate
Baclofen and Carbinoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbinoxamine is a sedating first-generation antihistamine, and combining it with baclofen can increase drowsiness, dizziness and impaired concentration. Anticholinergic effects may add to confusion in older adults.
What this interaction means in plain words
Baclofen and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Carbinoxamine belongs to Respiratory.
Why it happens
Additive CNS depression from central H1 antagonism and baclofen GABA-B agonism.
What to do
Monitor for oversedation and consider a non-sedating antihistamine if appropriate. Advise patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Baclofen and Carbinoxamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Baclofen
Other interactions of Carbinoxamine
- Alprazolam + Carbinoxamine Moderate
- Amisulpride + Carbinoxamine Moderate
- Amitriptyline + Carbinoxamine Moderate
- Amobarbital + Carbinoxamine Moderate
- Asenapine + Carbinoxamine Moderate
- Azelastine-fluticasone + Carbinoxamine Moderate
Frequently asked questions
Can I take Baclofen with Carbinoxamine?
MediHelp rates the interaction as moderate. Baclofen and Carbinoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbinoxamine is a sedating first-generation antihistamine, and combining it with baclofen can increase drowsiness, dizziness and impaired concentration. Anticholinergic effects may add to confusion in older adults.
How serious is the interaction between Baclofen and Carbinoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider a non-sedating antihistamine if appropriate. Advise patients to avoid driving and alcohol.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
