Drug interactions
Baclofen + Cariprazine
Severity: Moderate
Baclofen and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine can cause somnolence and impair judgement and motor skills. Combined with baclofen, sedation and dizziness may be greater.
What this interaction means in plain words
Baclofen and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Cariprazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from baclofen and the antipsychotic cariprazine.
What to do
Monitor for sedation, orthostasis and falls, especially during initiation or dose increases. Adjust baclofen dose if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Cariprazine
Frequently asked questions
Can I take Baclofen with Cariprazine?
MediHelp rates the interaction as moderate. Baclofen and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine can cause somnolence and impair judgement and motor skills. Combined with baclofen, sedation and dizziness may be greater.
How serious is the interaction between Baclofen and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostasis and falls, especially during initiation or dose increases. Adjust baclofen dose if drowsiness is excessive.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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