Drug interactions
Baclofen + Chlorzoxazone
Severity: Moderate
Baclofen and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are centrally acting muscle relaxants that cause drowsiness and dizziness. Combined use can increase sedation and impair psychomotor performance.
What this interaction means in plain words
Baclofen and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Chlorzoxazone belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects of two centrally acting muscle relaxants.
What to do
Avoid duplicate muscle relaxant therapy where possible. If both are used, keep doses low and monitor for sedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Baclofen with Chlorzoxazone?
MediHelp rates the interaction as moderate. Baclofen and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are centrally acting muscle relaxants that cause drowsiness and dizziness. Combined use can increase sedation and impair psychomotor performance.
How serious is the interaction between Baclofen and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate muscle relaxant therapy where possible. If both are used, keep doses low and monitor for sedation and falls.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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