Drug interactions
Baclofen + Cyclizine
Severity: Moderate
Baclofen and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is a sedating antihistamine antiemetic. Together with baclofen it can increase drowsiness and impair alertness.
What this interaction means in plain words
Baclofen and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Cyclizine belongs to Respiratory.
Why it happens
Additive CNS depression from H1 antagonism and baclofen's GABA-B agonism.
What to do
Counsel about drowsiness and avoid driving until the response is known. Consider a less sedating antiemetic if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Baclofen with Cyclizine?
MediHelp rates the interaction as moderate. Baclofen and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is a sedating antihistamine antiemetic. Together with baclofen it can increase drowsiness and impair alertness.
How serious is the interaction between Baclofen and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about drowsiness and avoid driving until the response is known. Consider a less sedating antiemetic if needed.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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