Drug interactions
Baclofen + Desipramine
Severity: Moderate
Baclofen and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is a tricyclic antidepressant, less sedating than some, but it can still cause drowsiness and orthostatic hypotension. With baclofen, CNS depression and muscle weakness may be increased, and both can lower the seizure threshold.
What this interaction means in plain words
Baclofen and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Desipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of a tricyclic antidepressant and a GABA-B agonist.
What to do
Monitor for sedation, hypotension and confusion, particularly in older adults. Adjust doses if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Baclofen with Desipramine?
MediHelp rates the interaction as moderate. Baclofen and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is a tricyclic antidepressant, less sedating than some, but it can still cause drowsiness and orthostatic hypotension. With baclofen, CNS depression and muscle weakness may be increased, and both can lower the seizure threshold.
How serious is the interaction between Baclofen and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, hypotension and confusion, particularly in older adults. Adjust doses if adverse effects appear.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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