Drug interactions
Baclofen + Doxepin
Severity: Moderate
Baclofen and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant, and with baclofen it can increase drowsiness, dizziness and falls. Both drugs have been associated with confusion, and baclofen may also potentiate tricyclic-related muscle hypotonia.
What this interaction means in plain words
Baclofen and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression from H1 antagonism and anticholinergic effects of doxepin with baclofen GABA-B agonism.
What to do
Start with low doses and monitor for sedation, confusion and falls, particularly in older adults. Advise against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Baclofen with Doxepin?
MediHelp rates the interaction as moderate. Baclofen and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant, and with baclofen it can increase drowsiness, dizziness and falls. Both drugs have been associated with confusion, and baclofen may also potentiate tricyclic-related muscle hypotonia.
How serious is the interaction between Baclofen and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and monitor for sedation, confusion and falls, particularly in older adults. Advise against alcohol and driving.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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