Drug interactions
Baclofen + Hydrocodone
Severity: Major
Baclofen and Hydrocodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Baclofen is a centrally acting muscle relaxant that can add to opioid sedation and respiratory depression. Combined use increases the risk of dizziness, falls, and overdose.
What this interaction means in plain words
Baclofen and Hydrocodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baclofen belongs to Musculoskeletal; Hydrocodone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression through GABA-B agonism and opioid receptor agonism.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Hydrocodone?
MediHelp rates the interaction as major. Baclofen and Hydrocodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Baclofen is a centrally acting muscle relaxant that can add to opioid sedation and respiratory depression. Combined use increases the risk of dizziness, falls, and overdose.
How serious is the interaction between Baclofen and Hydrocodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Counsel patients to avoid driving and alcohol.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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