Drug interactions
Baclofen + Maprotiline
Severity: Moderate
Baclofen and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a sedating tetracyclic antidepressant that lowers seizure threshold, and with baclofen it may cause additive drowsiness and confusion. Seizure risk may also be increased.
What this interaction means in plain words
Baclofen and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-B agonism and antihistaminic and adrenergic blockade, with additive seizure-threshold lowering.
What to do
Monitor for oversedation and seizure activity, and use the lowest effective doses. Avoid abrupt baclofen withdrawal, which itself can cause seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Baclofen with Maprotiline?
MediHelp rates the interaction as moderate. Baclofen and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a sedating tetracyclic antidepressant that lowers seizure threshold, and with baclofen it may cause additive drowsiness and confusion. Seizure risk may also be increased.
How serious is the interaction between Baclofen and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and seizure activity, and use the lowest effective doses. Avoid abrupt baclofen withdrawal, which itself can cause seizures.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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