Drug interactions
Baclofen + Metaxalone
Severity: Moderate
Baclofen and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are muscle relaxants with sedative effects, and combined use can increase drowsiness, dizziness and weakness. Concurrent use offers little added benefit and raises the risk of falls.
What this interaction means in plain words
Baclofen and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from two centrally acting skeletal muscle relaxants.
What to do
Avoid combining muscle relaxants when possible. If used together, monitor sedation and counsel on driving and fall risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Metaxalone
Frequently asked questions
Can I take Baclofen with Metaxalone?
MediHelp rates the interaction as moderate. Baclofen and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are muscle relaxants with sedative effects, and combined use can increase drowsiness, dizziness and weakness. Concurrent use offers little added benefit and raises the risk of falls.
How serious is the interaction between Baclofen and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining muscle relaxants when possible. If used together, monitor sedation and counsel on driving and fall risk.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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