Drug interactions
Baclofen + Oxymorphone
Severity: Moderate
Baclofen and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can cause marked sedation, weakness, confusion and respiratory depression. Risk is higher in elderly patients, those with renal impairment, and at high doses.
What this interaction means in plain words
Baclofen and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid receptor agonism and GABA-B agonism by baclofen.
What to do
Use the lowest effective doses and titrate slowly, monitoring sedation and respiratory function. Reduce baclofen dose in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Baclofen
Frequently asked questions
Can I take Baclofen with Oxymorphone?
MediHelp rates the interaction as moderate. Baclofen and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can cause marked sedation, weakness, confusion and respiratory depression. Risk is higher in elderly patients, those with renal impairment, and at high doses.
How serious is the interaction between Baclofen and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly, monitoring sedation and respiratory function. Reduce baclofen dose in renal impairment.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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