Drug interactions
Baclofen + Secobarbital
Severity: Major
Baclofen and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and baclofen both depress the CNS, so together they can cause profound sedation, respiratory depression and impaired consciousness. The risk is greater with higher doses, in older patients, or with renal impairment that prolongs baclofen exposure.
What this interaction means in plain words
Baclofen and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Baclofen belongs to Musculoskeletal; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-B agonism and barbiturate enhancement of GABA-A receptor activity.
What to do
Avoid the combination where possible; if needed, use reduced doses of both and monitor level of consciousness and respiration. Do not combine with alcohol or other sedatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Baclofen
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Baclofen with Secobarbital?
MediHelp rates the interaction as major. Baclofen and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates and baclofen both depress the CNS, so together they can cause profound sedation, respiratory depression and impaired consciousness. The risk is greater with higher doses, in older patients, or with renal impairment that prolongs baclofen exposure.
How serious is the interaction between Baclofen and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, use reduced doses of both and monitor level of consciousness and respiration. Do not combine with alcohol or other sedatives.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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