Drug interactions
Baclofen + Ziprasidone
Severity: Moderate
Baclofen and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and dizziness, so combined use may increase sedation and impair coordination. Ziprasidone has less orthostatic effect than some antipsychotics but the additive sedation can still affect safety.
What this interaction means in plain words
Baclofen and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baclofen belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-B agonism and ziprasidone antihistaminic and antiadrenergic activity.
What to do
Monitor for sedation and dizziness when starting or adjusting either drug and counsel patients about driving. Reduce doses if daytime impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baclofen
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Baclofen with Ziprasidone?
MediHelp rates the interaction as moderate. Baclofen and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and dizziness, so combined use may increase sedation and impair coordination. Ziprasidone has less orthostatic effect than some antipsychotics but the additive sedation can still affect safety.
How serious is the interaction between Baclofen and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness when starting or adjusting either drug and counsel patients about driving. Reduce doses if daytime impairment occurs.
What other medicines interact with Baclofen?
MediHelp also lists interactions of Baclofen with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Baclofen page.
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