Drug interactions
Balsalazide + Probenecid
Severity: Minor
Balsalazide and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mesalamine metabolites are organic anions and may compete with probenecid for renal tubular secretion. Systemic exposure is low, so any effect is likely small.
What this interaction means in plain words
Balsalazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Balsalazide belongs to Gastrointestinal Tract; Probenecid belongs to Genitourinary.
Why it happens
Theoretical competition for renal tubular anion secretion.
What to do
No routine adjustment; monitor uricosuric response and renal function if used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Balsalazide
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Balsalazide with Probenecid?
MediHelp rates the interaction as minor. Balsalazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mesalamine metabolites are organic anions and may compete with probenecid for renal tubular secretion. Systemic exposure is low, so any effect is likely small.
How serious is the interaction between Balsalazide and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor uricosuric response and renal function if used long term.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Balsalazide page.
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