Drug interactions
Balsalazide + Sulindac
Severity: Minor
Balsalazide and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulindac and its metabolites are organic acids that could compete with balsalazide metabolites for renal tubular secretion. The effect is probably small. Both drugs can affect renal function, and NSAIDs may worsen colitis.
What this interaction means in plain words
Balsalazide and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Balsalazide belongs to Gastrointestinal Tract; Sulindac belongs to Musculoskeletal.
Why it happens
Possible competition for renal tubular anionic secretion; this is largely theoretical.
What to do
No dose change is needed; monitor renal function and colitis symptoms with prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Balsalazide and Sulindac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Balsalazide
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Balsalazide with Sulindac?
MediHelp rates the interaction as minor. Balsalazide and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulindac and its metabolites are organic acids that could compete with balsalazide metabolites for renal tubular secretion. The effect is probably small. Both drugs can affect renal function, and NSAIDs may worsen colitis.
How serious is the interaction between Balsalazide and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor renal function and colitis symptoms with prolonged co-therapy.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Balsalazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
