Drug interactions
Balsalazide + Tolazamide
Severity: Minor
Balsalazide and Tolazamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at large doses can enhance the glucose-lowering effect of sulfonylureas. Balsalazide delivers only small amounts of systemic salicylate as mesalamine, so a meaningful effect on tolazamide is unlikely.
What this interaction means in plain words
Balsalazide and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Balsalazide belongs to Gastrointestinal Tract; Tolazamide belongs to Endocrine.
Why it happens
Possible displacement of the sulfonylurea from plasma proteins and a direct glucose-lowering effect of salicylate at high doses.
What to do
No dose change is needed. Continue routine blood glucose monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Balsalazide
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Balsalazide with Tolazamide?
MediHelp rates the interaction as minor. Balsalazide and Tolazamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salicylates at large doses can enhance the glucose-lowering effect of sulfonylureas. Balsalazide delivers only small amounts of systemic salicylate as mesalamine, so a meaningful effect on tolazamide is unlikely.
How serious is the interaction between Balsalazide and Tolazamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Continue routine blood glucose monitoring.
What other medicines interact with Balsalazide?
MediHelp also lists interactions of Balsalazide with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Balsalazide page.
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