Drug interactions
Baricitinib + Ethacrynic acid
Severity: Moderate
Baricitinib and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid may inhibit renal organic anion transporter 3 and reduce the tubular secretion of baricitinib. Exposure to baricitinib can rise, increasing the chance of dose-related adverse effects such as infection, cytopenias and lipid elevations.
What this interaction means in plain words
Baricitinib and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Inhibition of OAT3-mediated renal tubular secretion of baricitinib reduces its elimination.
What to do
Monitor for infections, blood counts and lipids, and consider an alternative diuretic if the combination is not essential. Follow the labeled baricitinib dose adjustment for OAT3 inhibitors where it applies.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Baricitinib with Ethacrynic acid?
MediHelp rates the interaction as moderate. Baricitinib and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid may inhibit renal organic anion transporter 3 and reduce the tubular secretion of baricitinib. Exposure to baricitinib can rise, increasing the chance of dose-related adverse effects such as infection, cytopenias and lipid elevations.
How serious is the interaction between Baricitinib and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infections, blood counts and lipids, and consider an alternative diuretic if the combination is not essential. Follow the labeled baricitinib dose adjustment for OAT3 inhibitors where it applies.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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