Drug interactions
Baricitinib + Mefenamic acid
Severity: Moderate
Baricitinib and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid may inhibit organic anion transporter 3 and reduce renal elimination of baricitinib, increasing its exposure. Higher levels could increase the risk of baricitinib adverse effects such as infection and cytopenias. The labeling advises against strong OAT3 inhibitors, and the inhibitory potency of mefenamic acid is less well defined.
What this interaction means in plain words
Baricitinib and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Inhibition of renal OAT3-mediated tubular secretion of baricitinib.
What to do
Consider an alternative analgesic. If the combination is needed, monitor for infection and blood count abnormalities and review baricitinib dosing per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Frequently asked questions
Can I take Baricitinib with Mefenamic acid?
MediHelp rates the interaction as moderate. Baricitinib and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid may inhibit organic anion transporter 3 and reduce renal elimination of baricitinib, increasing its exposure. Higher levels could increase the risk of baricitinib adverse effects such as infection and cytopenias. The labeling advises against strong OAT3 inhibitors, and the inhibitory potency of mefenamic acid is less well defined.
How serious is the interaction between Baricitinib and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative analgesic. If the combination is needed, monitor for infection and blood count abnormalities and review baricitinib dosing per labeling.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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