Drug interactions
Baricitinib + Trastuzumab deruxtecan
Severity: Moderate
Baricitinib and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab deruxtecan can cause neutropenia and other myelosuppression, and baricitinib adds immunosuppression. Together they may increase the risk of serious infection.
What this interaction means in plain words
Baricitinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Baricitinib belongs to Musculoskeletal; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive immunosuppression and myelosuppression from JAK inhibition and cytotoxic antibody-drug conjugate payload.
What to do
Monitor blood counts and for signs of infection, and review the need for baricitinib during cytotoxic therapy. Interrupt baricitinib if serious infection or severe neutropenia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Baricitinib
- Adenovirus types 4 and 7 live + Baricitinib Contraindicated
- Baricitinib + Bcg vaccine live Contraindicated
- Baricitinib + Tofacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Abatacept + Baricitinib Major
- Adalimumab + Baricitinib Major
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Baricitinib with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Baricitinib and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab deruxtecan can cause neutropenia and other myelosuppression, and baricitinib adds immunosuppression. Together they may increase the risk of serious infection.
How serious is the interaction between Baricitinib and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection, and review the need for baricitinib during cytotoxic therapy. Interrupt baricitinib if serious infection or severe neutropenia occurs.
What other medicines interact with Baricitinib?
MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Tofacitinib. The full list is on the Baricitinib page.
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