Drug interactions
Basiliximab + Rilonacept
Severity: Moderate
Basiliximab and Rilonacept: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress immune function through different pathways, so combined use may increase the risk of serious infection. Clinical data on this specific pairing are limited.
What this interaction means in plain words
Basiliximab and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Basiliximab belongs to Miscellaneous; Rilonacept belongs to Miscellaneous.
Why it happens
Additive immunosuppression from IL-2 receptor blockade and IL-1 inhibition.
What to do
Avoid starting rilonacept during active infection and monitor for signs of infection throughout combined therapy. Reassess the need for rilonacept in the perioperative transplant period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Basiliximab
- Basiliximab + Bcg vaccine live Contraindicated
- Basiliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine live Contraindicated
- Basiliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Basiliximab + Measles vaccine Contraindicated
Other interactions of Rilonacept
Frequently asked questions
Can I take Basiliximab with Rilonacept?
MediHelp rates the interaction as moderate. Basiliximab and Rilonacept can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress immune function through different pathways, so combined use may increase the risk of serious infection. Clinical data on this specific pairing are limited.
How serious is the interaction between Basiliximab and Rilonacept?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting rilonacept during active infection and monitor for signs of infection throughout combined therapy. Reassess the need for rilonacept in the perioperative transplant period.
What other medicines interact with Basiliximab?
MediHelp also lists interactions of Basiliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Basiliximab page.
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