Drug interactions
Bazedoxifene-conjugated estrogens + Cimetidine
Severity: Minor
Bazedoxifene-conjugated estrogens and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak, non-selective inhibitor of CYP enzymes and may modestly raise estrogen exposure. The effect is generally small and clinically manageable.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of CYP3A4 and other hepatic enzymes by cimetidine slightly reduces estrogen metabolism.
What to do
No routine adjustment is needed. Watch for estrogen excess effects such as breast tenderness or nausea and consider an H2 blocker like famotidine if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Cimetidine?
MediHelp rates the interaction as minor. Bazedoxifene-conjugated estrogens and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine is a weak, non-selective inhibitor of CYP enzymes and may modestly raise estrogen exposure. The effect is generally small and clinically manageable.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for estrogen excess effects such as breast tenderness or nausea and consider an H2 blocker like famotidine if these occur.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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