Drug interactions
Bazedoxifene-conjugated estrogens + Maprotiline
Severity: Minor
Bazedoxifene-conjugated estrogens and Maprotiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estrogens may increase concentrations of tricyclic-type antidepressants, raising sedation, anticholinergic effects and seizure or cardiac risk. Evidence for maprotiline specifically is limited.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Maprotiline belongs to Central Nervous System.
Why it happens
Possible estrogen-mediated inhibition of antidepressant metabolism; extrapolated from tricyclics.
What to do
Monitor tolerability and depressive symptoms when estrogen is started or stopped and adjust the maprotiline dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Maprotiline?
MediHelp rates the interaction as minor. Bazedoxifene-conjugated estrogens and Maprotiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Estrogens may increase concentrations of tricyclic-type antidepressants, raising sedation, anticholinergic effects and seizure or cardiac risk. Evidence for maprotiline specifically is limited.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Maprotiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tolerability and depressive symptoms when estrogen is started or stopped and adjust the maprotiline dose if needed.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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