Drug interactions
Bazedoxifene / conjugated estrogens + Nevirapine
Severity: Moderate
Bazedoxifene / conjugated estrogens and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine may lower exposure to the estrogen component through CYP3A4 induction, reducing control of menopausal symptoms. Reduced bazedoxifene effect on endometrial protection is also possible.
What this interaction means in plain words
Bazedoxifene / conjugated estrogens and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nevirapine induces CYP3A4 and enhances estrogen and bazedoxifene metabolism.
What to do
Monitor for recurrent vasomotor symptoms or abnormal bleeding. Report any unexpected vaginal bleeding for evaluation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Bazedoxifene / conjugated estrogens with Nevirapine?
MediHelp rates the interaction as moderate. Bazedoxifene / conjugated estrogens and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine may lower exposure to the estrogen component through CYP3A4 induction, reducing control of menopausal symptoms. Reduced bazedoxifene effect on endometrial protection is also possible.
How serious is the interaction between Bazedoxifene / conjugated estrogens and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for recurrent vasomotor symptoms or abnormal bleeding. Report any unexpected vaginal bleeding for evaluation.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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