Drug interactions
Bazedoxifene-conjugated estrogens + Roxithromycin
Severity: Minor
Bazedoxifene-conjugated estrogens and Roxithromycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A theoretical reduction in estrogen recirculation through gut flora changes has been proposed for antibiotics, but evidence for roxithromycin is lacking. Clinical impact on conjugated estrogens is likely negligible.
What this interaction means in plain words
Bazedoxifene-conjugated estrogens and Roxithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Roxithromycin belongs to Anti Bacterial.
Why it happens
Theoretical reduction of enterohepatic estrogen recirculation through altered intestinal flora; not well established.
What to do
No adjustment is needed; reassess symptoms only if vasomotor symptoms return during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens Contraindicated
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Antithrombin alfa + Bazedoxifene-conjugated estrogens Major
- Antithrombin iii + Bazedoxifene-conjugated estrogens Major
- Bazedoxifene-conjugated estrogens + Bemiparin Major
- Bazedoxifene-conjugated estrogens + Carbamazepine Major
Other interactions of Roxithromycin
- Digoxin + Roxithromycin Major
- Argatroban + Roxithromycin Moderate
- Cyclosporin + Roxithromycin Moderate
- Roxithromycin + Tacrolimus Moderate
- Ampicillin-sulbactam + Roxithromycin Minor
- Ampicillin + Roxithromycin Minor
Frequently asked questions
Can I take Bazedoxifene-conjugated estrogens with Roxithromycin?
MediHelp rates the interaction as minor. Bazedoxifene-conjugated estrogens and Roxithromycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. A theoretical reduction in estrogen recirculation through gut flora changes has been proposed for antibiotics, but evidence for roxithromycin is lacking. Clinical impact on conjugated estrogens is likely negligible.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Roxithromycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed; reassess symptoms only if vasomotor symptoms return during therapy.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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