Drug interactions
Bcg vaccine live + Dupilumab
Severity: Moderate
Bcg vaccine live and Dupilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dupilumab alters type 2 immune signaling, and safety of live vaccines in treated patients has not been established. A live BCG organism could in theory cause disseminated infection or the vaccine response could be impaired.
What this interaction means in plain words
Bcg vaccine live and Dupilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dupilumab blocks IL-4/IL-13 signaling, which may alter the response to live attenuated organisms; the effect is theoretical.
What to do
Give needed live vaccines before starting dupilumab, and avoid live vaccines during therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bcg vaccine live and Dupilumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dupilumab
Frequently asked questions
Can I take Bcg vaccine live with Dupilumab?
MediHelp rates the interaction as moderate. Bcg vaccine live and Dupilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dupilumab alters type 2 immune signaling, and safety of live vaccines in treated patients has not been established. A live BCG organism could in theory cause disseminated infection or the vaccine response could be impaired.
How serious is the interaction between Bcg vaccine live and Dupilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give needed live vaccines before starting dupilumab, and avoid live vaccines during therapy.
What other medicines interact with Dupilumab?
MediHelp also lists interactions of Dupilumab with, for example, Smallpox vaccine live, Adenovirus types 4 and 7 live, Cyclosporine. The full list is on the Dupilumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
