Drug interactions
Dupilumab + Influenza virus vaccine quadrivalent intranasal
Severity: Moderate
Dupilumab and Influenza virus vaccine quadrivalent intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal influenza vaccine contains live attenuated virus, and its safety in patients on dupilumab has not been established. Altered immune signaling could in theory permit vaccine virus replication or reduce the response, and many patients treated have atopic disease or asthma, where the live nasal vaccine is itself of concern.
What this interaction means in plain words
Dupilumab and Influenza virus vaccine quadrivalent intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Dupilumab blocks IL-4/IL-13 signaling, which may alter immune handling of live attenuated virus; the effect is largely theoretical.
What to do
Use an inactivated injectable influenza vaccine instead of the intranasal live product.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dupilumab
- Dupilumab + Smallpox vaccine live Major
- Adenovirus types 4 and 7 live + Dupilumab Moderate
- Bcg vaccine live + Dupilumab Moderate
- Cyclosporine + Dupilumab Moderate
- Disopyramide + Dupilumab Moderate
- Dupilumab + Fosphenytoin Moderate
Frequently asked questions
Can I take Dupilumab with Influenza virus vaccine quadrivalent intranasal?
MediHelp rates the interaction as moderate. Dupilumab and Influenza virus vaccine quadrivalent intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal influenza vaccine contains live attenuated virus, and its safety in patients on dupilumab has not been established. Altered immune signaling could in theory permit vaccine virus replication or reduce the response, and many patients treated have atopic disease or asthma, where the live nasal vaccine is itself of concern.
How serious is the interaction between Dupilumab and Influenza virus vaccine quadrivalent intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an inactivated injectable influenza vaccine instead of the intranasal live product.
What other medicines interact with Dupilumab?
MediHelp also lists interactions of Dupilumab with, for example, Smallpox vaccine live, Adenovirus types 4 and 7 live, Bcg vaccine live. The full list is on the Dupilumab page.
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