Drug interactions
Disopyramide + Dupilumab
Severity: Moderate
Disopyramide and Dupilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dupilumab may reverse cytokine-driven suppression of CYP enzymes, which could change the clearance of CYP3A4 substrates. Disopyramide has a narrow therapeutic index and is a CYP3A4 substrate, so levels could fall and arrhythmia control could change. The effect is theoretical.
What this interaction means in plain words
Disopyramide and Dupilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Dupilumab belongs to Respiratory.
Why it happens
Normalization of cytokine-suppressed CYP450 expression after IL-4 receptor blockade, potentially increasing disopyramide metabolism.
What to do
Monitor ECG and antiarrhythmic response, and serum disopyramide levels where available, when dupilumab is started or stopped. Adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dupilumab
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Dupilumab?
MediHelp rates the interaction as moderate. Disopyramide and Dupilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dupilumab may reverse cytokine-driven suppression of CYP enzymes, which could change the clearance of CYP3A4 substrates. Disopyramide has a narrow therapeutic index and is a CYP3A4 substrate, so levels could fall and arrhythmia control could change. The effect is theoretical.
How serious is the interaction between Disopyramide and Dupilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and antiarrhythmic response, and serum disopyramide levels where available, when dupilumab is started or stopped. Adjust the dose accordingly.
What other medicines interact with Dupilumab?
MediHelp also lists interactions of Dupilumab with, for example, Smallpox vaccine live, Adenovirus types 4 and 7 live, Bcg vaccine live. The full list is on the Dupilumab page.
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