Drug interactions
Cyclosporine + Dupilumab
Severity: Moderate
Cyclosporine and Dupilumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Blocking IL-4/IL-13 signaling may reverse cytokine-mediated suppression of CYP enzymes seen in chronic type 2 inflammation. This could modestly lower exposure to CYP3A substrates such as cyclosporine, which has a narrow therapeutic index. The effect is predicted rather than well demonstrated.
What this interaction means in plain words
Cyclosporine and Dupilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Normalization of cytokine-suppressed CYP450 expression after IL-4 receptor blockade, potentially increasing cyclosporine metabolism.
What to do
Monitor cyclosporine trough concentrations and clinical response when dupilumab is started or stopped. Adjust the cyclosporine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dupilumab
Frequently asked questions
Can I take Cyclosporine with Dupilumab?
MediHelp rates the interaction as moderate. Cyclosporine and Dupilumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blocking IL-4/IL-13 signaling may reverse cytokine-mediated suppression of CYP enzymes seen in chronic type 2 inflammation. This could modestly lower exposure to CYP3A substrates such as cyclosporine, which has a narrow therapeutic index. The effect is predicted rather than well demonstrated.
How serious is the interaction between Cyclosporine and Dupilumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and clinical response when dupilumab is started or stopped. Adjust the cyclosporine dose as needed.
What other medicines interact with Dupilumab?
MediHelp also lists interactions of Dupilumab with, for example, Smallpox vaccine live, Adenovirus types 4 and 7 live, Bcg vaccine live. The full list is on the Dupilumab page.
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